Researchers produce viable tissues of liver in bioprinting

Shaochen-Chen-UC-San-Diego If, for several years now, known to print various living cells, print a viable and functional whole body still in the field of foresight. However, research in the field of the bioprinting advance quickly, especially on the liver. A team from looking for the University of San Diego comes to take a decisive step towards a functional liver printing.

A structure 3D printed from stem cells, but not yet a full liver

Research on organs 3D printing advances and U.S. team from Shaochen Chen, Professor of NanoEngineering at the University of San Diego comes to a new stage. 3D structure liver their goal is to print a functional liver that can be implanted in a patient requiring a transplant. In appearance, the structure that researchers have managed to produce does not really resemble a liver as is usual in the anatomy books, and yet progress is immense. The structure three-dimensional developed by researchers reproduced the complex human liver venous network. A complex system has reproduced as a willing human liver of a double network which the pressure is different. Interlaced networks that allow the liver to destroy toxins in the blood.

This artificial liver consists of hexagonal structures of 900 microns consisting of human cells created from stem cells. A structure of 3 min to 3 min is printed in seconds against several hours via conventional bioprinting techniques. However the researchers will have to find how to print endothelial cells and mesenchymal areas separating the hexagons.

For now, this 3D structure was grown 20 days in vitro and was able to synthesize albumin and urea as a real liver. It is obviously not yet possible to establish such a structure in a patient.


hexagonal structures printed by researchers from the University of San Diego.

However due to lifetime of potentially greater than cell cultures must allow testing new treatments more quickly than via animal experiments and tests on humans. Develop a drug application on average a dozen year and 90% do not pass these tests in vivo. According to the researcher, with an artificial liver, this phase of testing may be greatly accelerated.

Translation : Bing Translator

Source: “Engineers 3D-print a New Lifelike Liver Tissue for Drug Screening”, press release of the University of San Diego, February 8, 2016

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